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Refrigeration slows the rate of chemical and physical degradation processes, including: Hydrolysis the breakdown of peptide bonds in the presence of water Oxidation damage to amino acid residues, particularly methionine and cysteine Aggregation the clumping of protein molecules, which may potentially trigger immune responses Deamidation chemical modification of asparagine and glutamine residues Clinical studies supporting the licensing of these medications were conducted using properly stored products
Yancey PH, Clark ME, Hand SC, Bowlus RD, Somero GN
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