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Aside from antioxidant metabolism and regulation in response to elevated ROS, cells also recruit components of the DNA damage response (DDR) pathway to cope with the potential damaging effect of free radicals on DNA 29,43
Structurally unique GLP-1-based medicines that achieve substantially greater and rapid weight loss may impact musculoskeletal health, providing a rationale for therapeutics that more selectively target adipose tissue loss while preserving muscle mass and strength
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