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Endocrine and metabolic effects of long-term administration of[ Nle27]growth hormone-releasing hormone-(129)-NH2 in age-advanced men and women

Treatment with hederagenin in lung cancer cells, leads to a strong upregulation of the CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues (Lu et al., 2024)

While compensatory angiogenesis serves as an adaptive mechanism to counteract tissue hypoxia in the aging brain, pathological angiogenesis can exacerbate neurodegenerative processes by promoting BBB dysfunction, inflammation, and vascular instability