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Key knowledge gaps There is a rapidly expanding body of literature on GLP-1RAs, but significant knowledge gaps persist
Synaptogenesis & dendritic spines Investigated in rodent tissue and cell models for its reported ability to increase dendritic spine density preclinical only, and the primary source assays were retracted in 2025
Oh, boy
Oxidative stress has been increased as a result of mitochondrial dysfunction, endothelial nitric oxide synthase (eNOS) uncoupling, resulting in endothelial dysfunction, the aberrant activity of NADPH oxidases (NOX), suppressed activity of antioxidant enzymes and low molecular weight antioxidants (Galvan et al
They therefore propose the use of a combination of either sulfasalazine or antioxidant machinery inhibitors along with ROS inducers such as BSO or chemotherapy for further preclinical testing [41]
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