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Whilst these medications offer significant therapeutic benefits, gastrointestinal side effectsincluding acid reflux and heartburnare commonly reported
To validate this mechanism, we conducted in in vivo and in vitro experiments
Intriguingly, recent studies have expanded the therapeutic scope of GLP-1RAs to neuroinflammatory regulation, with promising therapeutic potential observed in neurodegenerative disorders including Alzheimers disease, Parkinsons disease, and amyotrophic lateral sclerosis [271, 272]
These differences might partly explain the neutral results of the EXSCEL trial with exenatide (22)
