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Studies in cell cultures and animal models indicate that GLP-1 receptor activation might reduce inflammation and oxidative stress in colonic tissuefactors implicated in cancer development

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Rocha, D.B

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However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively

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