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The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality
PMID: 29 DomotoT.KiseK.OyamaY.FuruyaK.KatoY.NishitaY.et al
In kidney studies, Glp1r/ knockout mice experienced worse nephritis and diabetic kidney damage
Proc Natl Acad Sci USA 117:2995929967
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