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Reduced inflammation prevents premature transition to catagen

Biomaterial-based therapies, such as decellularized scaffolds and hydrogels, modulate immune cell behavior to improve inflammatory microenvironments and support tissue regeneration, with preclinical validation demonstrating biocompatibility and efficacy, laying the groundwork for early-phase trials (237, 238)

The SSS can also serve agriculture as a biofertilizer, soil conditioner, and plant disease suppressor, contributing to enhanced crop yield and soil health

Outlook The majority of strategies discussed in this review focus on enzyme-cleavable hydrogels for delivery of therapeutics, with a particular emphasis on MMP-degradable hydrogels

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