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These cover a wide range of conditions including obesity without comorbidities, type 2 diabetes, sleep apnea, chronic low back pain, and metabolic liver disease

DPP-4 inhibitors may be preferred for: Patients unable or unwilling to use injectable therapies Elderly individuals where the lower hypoglycaemia risk is particularly valuable Those at high risk of hypoglycaemia from other medications Patients requiring modest glycaemic improvements Individuals where weight neutrality is acceptable or desired Important cautions and contraindications: Do not combine a GLP-1 receptor agonist with a DPP-4 inhibitor

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This can be a sign of serious side effects, including a condition called gastroparesis (stomach paralysis) or bowel obstruction

Now a growing number of researchers, payers and providers are exploring deliberate "deprescription," which aims to taper some patients off their medication after they have taken it for a certain amount of time or lost a certain amount of weight