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In MDA-MB-231 breast cancer cells, Lcn2 inhibition was shown to promote erastin-mediated ferroptosis, leading to reduced tumor cell proliferation, metastasis, and enhanced chemosensitivity to cisplatin ( in vitro and in vivo studies that chemotherapy resistance to gefitinib in TNBC is associated with GPX4-mediated oxidative stress
Moreover, artificial tightening of MERCs in human fibroblasts leads to the induction of cellular senescence, a heightened proinflammatory secretory profile, and increased ROS production [106]
doi: 10.3390/IJERPH17020489 87
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2020;9(4):IJH31
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