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The most common side effects in the retatrutide group were gastrointestinal symptoms, which were dose-dependent and mostly mild to moderate in severity
doi: 10.1038/nature19084 25 NwosuZCWardMHSajjakulnukitPPoudelPRagulanCKasperekSet al
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For individuals dealing with chronic pain that interferes with sleep, DSIP's combined analgesic and sleep-promoting effects could be particularly relevant
Moreover, GLP-1R desensitization and internalization following repeated stimulation complicate dose escalation strategies and necessitate prolonged efficacy monitoring
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