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A shortage can lead to brittle nails, thinning hair, and changes in skin tone
doi: 10.3389/fimmu.2024.1355983 40 CohetCvan der MostRBauchauVBekkat-BerkaniRDohertyTMSchuindAet al
"Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia"
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However, if 5-Amino-1MQ also improves insulin sensitivity (as suggested in animal models), combined use particularly alongside insulin or sulfonylureas could theoretically increase the risk of low blood sugar to a clinically significant degree
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