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In addition, zonal differences in hepatic insulin signaling, non-classical insulin signaling pathways, and activation of the mechanistic target of rapamycin complex 1 and protein kinase C pathways appear to be involved in the development of selective hepatic IR
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Mol Endocrinol 18:18591875 Ortega I, Sokalska A, Villanueva JA, Cress AB, Wong DH, Stener VE, Scott D, Stanley SD, Duleba AJ (2013) Letrozole increases ovarian growth and Cyp17a1
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Most studies involving IGF-1 LR3 have focused on its effects in peripheral tissues rather than its direct actions within the central nervous system, so more research is needed to determine its distribution in the brain
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