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When weight loss occurs gradually, the skin's fibroblasts can continue producing collagen and elastin, allowing it to retract more effectively, but with rapid or significant weight loss, the skin's ability to contract is overwhelmed, leading to lax tissue and an inability to snap back

Fadl YY, Krumholz HM , Kosiborod M, Masoudi FA, Peterson PN, Reid KJ, Weintraub WS, Buchanan DM, Spertus JA