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Expert reviews, including a recent UC San Diego analysis, conclude that the biological mechanism needed for an immediate effect simply doesnt exist
A healthy, unstressed cell maintains a vast majority of its glutathione pool in the reduced state, typically sustaining a GSH-to-GSSG ratio of greater than 10:1, and often up to 100:1 in the cytosol
Upon intravenous administration, ascorbic acid rapidly increases plasma concentrations, bypassing the limitations of gastrointestinal absorption that restrict oral dosing
& Gao, J
GSTs conjugate molecules, including xenobiotics, with GSH, and then, this conjugated molecules can be actively transported to extracellular medium by ABCC transporters
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