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1315 population doublings as per previous Gecko v1 screens), MAGeCK RRA overrepresentation analysis of genes enhanced in 5FU groups at endpoint showed that OxPhos genes were highly enriched (Fig

K.ChoiB

Moreover, uracil, n-oleoylethanolamine, asymmetric (ADMA) and symmetric (SDMA) dimethylarginines (protein degradation residues), palmitoylglycerol (active metabolite) and pseudouridine (nucleotide metabolism) were depleted in T4 only, whereas -muricholic acid (bile acid) was depleted in T5