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Diarrhea (loose stool)
Yes, and this is a common strategy
32 The low GSH group, but not the other two groups, experienced improved exercise performance, improved GSH status and oxidative stress with NAC 1200 mg per day for 30 days compared with placebo
28 note to investors, William Blair analysts wrote that Applied Therapeutics suspects the CRL was related to the efficacy package as opposed to [chemistry, manufacturing and controls] or safety. Results from the Phase III ACTION-Galactosemia Kids study, unveiled in April 2023, showed that govorestat fell short of its primary efficacy endpoint, a composite of four clinical measures designed to assess various domains of galactosemia symptoms
The mechanism of action isnt well understood, but its believed it doesnt affect the tendon tissue cells directly, but rather that either works by activating other repair cells that can help tendons or ligaments or making the human growth factor receptor on the repair cells more sensitive (3)
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