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doi: 10.1186/s13063-019-3996-x 94
however, metabolic adaptation and GLP-1 receptor signaling take longer to normalize
Additional safety considerations include risk of dehydration and acute kidney injury, potential worsening of diabetic retinopathy with rapid glucose improvement (particularly with semaglutide), and hypoglycemia risk when combined with insulin or sulfonylureas
Patient Education and Support Effective patient education about Semaglutide use, potential side effects, and treatment adherence is essential
Are there alternative GLP-1s with fewer gastrointestinal side effects
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