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in preclinical models it activates the VEGFR2-Akt-eNOS signaling axis to promote angiogenesis and tissue vascularization ( It also engages ERK1/2 and FAK-paxillin pathways that regulate endothelial cell migration and fibroblast activity, and upregulates heat shock proteins (HSP70/90) for cytoprotective effects in gastrointestinal tissue models ( Research across multiple rodent injury models has characterized its activity in tendon, muscle, nerve, and GI tissue contexts
& Averill-Bates, D
doi: 10.1016/j.jsbmb.2023.106254 129 JonesLAAnthonyJ-PHenriquezFLLyonsRENickdelMBCarterKCet al
Pregnant or breastfeeding women should talk to their doctor before getting B12 injections
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