Blair, Y., Wessells, H., Pop-Busui, R., Ang, L
The compound demonstrates a therapeutic effect similar to Fer-1, making it a promising treatment option for PPO
By contrast, Xu et al (213), using CT26 and SW480 models together with endothelial C166 cells and patient-derived xenografts, reported that GCG administered at 10 nM in vitro and 20 g per mouse daily in vivo for ~14 days inhibited tumor angiogenesis and vascular mimicry and enhanced chemotherapy efficacy, without measurable differences in blood glucose levels among groups
They are capable of distinguishing healthy cells from aberrant cells, the latter often exhibiting downregulated or absent major histocompatibility complex (MHC) class I molecules (226)
doi:10.1111/j.1460-9568.2011.07957.x