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Future research should prioritize longitudinal cohort studies with precise exposure metrics, integrated with mechanistic experiments to bridge the critical gap between animal models and human pathophysiology
Zeng Z, Konopleva M, Estrov Z, Hu W, Carlson-Bremer D, Harris D, Carter BZ, Milella M, Lu Y, Mills GB, Andreeff M
It is initiated during the ischemia stage due to energy metabolism disorders and further amplified during the reperfusion stage due to a surge in ROS, severely disrupting cellular homeostasis and organ function
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