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You can also read more about tirzepatide in our post on how long tirzepatide takes to work

Future randomized controlled trials are necessary to confirm the efficacy and safety in this high-risk population.

Women with both PCOS and obesity exhibit high levels of insulin resistance

Thyroid meds (levothyroxine or liothyronine): separate by several hours and monitor, as carnitine can reduce tissue responsiveness

In selected cases of severe, treatment-resistant lymphoedema, surgical options such as liposuction (covered by NICE interventional procedures guidance), lymphaticovenous anastomosis, or vascularised lymph node transfer may be considered at specialist centres, though these remain relatively uncommon