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The magnitude of heart rate increase in clinical trials was generally small and not clinically significant for most participants

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Clinical Studies The effectiveness of alogliptin and pioglitazone tablets has been established based on four adequate and well-controlled Phase 3 trials of alogliptin and pioglitazone as adjunct to diet to improve glycemic control in adult patients with type 2 diabetes mellitus

But while thats an important part of how the medication works, the delayed stomach emptying may increase the risk of pulmonary aspiration during general anesthesia or deep sedation