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Systemic inflammatory cytokines such as TNF-, interferon-beta (IFN-), and various interleukins exacerbating cognitive and motor dysfunction have been identified in various neurodegenerative diseases, including ALS [2629]
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Folate deficiency caused by a lack of dietary folate is more common in people who have a generally unbalanced and unhealthy diet, people who regularly misuse alcohol, and people following a restrictive diet that does not involve eating good sources of folate
Nrf2 inhibitors also sensitize cancers to the effects of chemotherapeutic drugs through the down-regulation of detoxification enzymes and drug excretion transporters (Singh et al., 2008
Cardiovasc Res 52:407416
