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[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes

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- Dosage: 2 mg to 5 mg twice per week for the first 4-6 weeks (loading phase), followed by 2 mg once per week (maintenance phase)

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