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Methods Animals and housing conditions Experiments were performed in accordance with the Animal Protection Law of the European Union after permission by the Government of Upper Bavaria, or the Eli Lilly and Company Institutional Animal Care and Use Committee
Furthermore, Y358 is locked in place by E383 and K436, an electrostatic pair conserved in OCTs and OATs 34 that is involved in the coordination and release of substrates within the pocket 29 (Supplementary Fig
These medications can temporarily reverse and block the effects of other opioids
Academic institutions, independent research organizations, or collaborative pharmaceutical initiatives could theoretically pursue these questions, though competitive dynamics make such studies unlikely in the near term
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