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The same group subsequently reported that BPC-157 modulates vasomotor tone by enhancing phosphorylation of Src, caveolin-1, and eNOS, and that the peptide reduces caveolin-1/eNOS binding a step that releases eNOS from caveolar inhibition and permits nitric oxide generation (Hsieh et al., 2020)
However, no human studies have examined truly long-term use extending over years or decades
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