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Gastrointestinal side effects discussed above like nausea, vomiting, and dehydration could potentially trigger or worsen mental health issues and patients with pre-existing mental health conditions may be more susceptible to adverse psychological effects
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However, a pronounced increase in HR may be associated with adverse clinical outcomes in subjects with both T2DM and advanced HF
In vivo pharmacodynamic studies in C57BL/6J mice demonstrated superior glucose tolerance at 72 hours post-dose for both analogs-42% (JK-1246R-011) and 44% (JK-1246R-012) improvements over Tirzepatide (AUC, n = 6)
