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When administered peripherally, particularly antibody-based GIPR antagonists demonstrate some potential to prevent the development of HFD-induced obesity in rodents (181, 186), but GIPR antagonists show only modest, if any ability to decrease body weight once obesity is already established (181, 183186)
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Following the success of GLP-1 receptor agonists, pharmaceutical research has shifted toward more complex, multi-hormonal therapies
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