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Key takeaways Nucala is an add-on interleukin-5 (IL-5) antagonist monoclonal antibody drug that treats severe eosinophilic asthma as well as other conditions and may reduce the need for corticosteroids

The standard dose may not achieve optimal tissue concentration

Theoretical and Class-Level Risks These have not been confirmed in cagrilintide trials but are flagged because they appear in related amylin or GLP-1 class data: pancreatitis, gallbladder disease, severe hypoglycemia (mainly when combined with insulin or sulfonylureas), and acute kidney injury secondary to dehydration from severe nausea or vomiting

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That said, several important safety considerations remain: No FDA approval : BPC-157 is not approved by the U.S