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Relative Contraindications and Cautions require careful consideration: History of pancreatitis : While not an absolute contraindication, patients with prior pancreatitis have increased risk of recurrence

Here are the key conditions and situations where its use may pose risks: Personal or family history of medullary thyroid carcinoma (MTC): Semaglutide GLP-1 carries a boxed warning because it has been associated with thyroid C-cell tumors in animal studies

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Hobson AR and Aziz Q: Modulation of visceral nociceptive pathways

One study found family history roughly doubles the risk