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Most manufacturers that isolate B12 into a single product feel like they need to give consumers their moneys worth, and so they pack in either 1,000 or 5,000 mcg doses
In developed countries, situations at greatest risk for deficiency include eating a diet restricted in fruits and vegetables, smoking or long-term exposure to secondhand smoke, and drug and alcohol abuse
Even the National Institutes of Health website will tell you there is no toxicity to B12
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