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The approval is supported by data from the Phase I/II TRIDENT-1 trial, where treatment with Augtyro resulted in a 58% confirmed objective response rate (cORR) in TKI-nave patients, of which 15% were complete responses

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However, emerging research suggests that these drugs may come with an unexpected riskan increased incidence of ischemic optic neuropathy, a condition closely related to ischemic retinopathy

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