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The more substantial weight reductions of 10-15% of body weight have been observed with higher-dose injectable semaglutide (2.4 mg) used specifically for obesity treatment, not with the Rybelsus formulation
Most people misread this as the supplement not agreeing with them and quit, when the real fix is simply starting with a dose and building up over two to three weeks as your gut adapts
B., Mestayer, R., Berg, J., Grant, R
doi: 10.1016/j.immuni.2022.06.007 79 XuLZhouJCheJWangHYangWZhouWet al
Sci Transl Med (2017) 9(379):eaa12408
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