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The experimental data from rats suggest that the inhibitory effect of GLP-1 on gastric motor function is mediated by the afferent vagal nerve, through interaction with GLP-1Rs located in vagal afferent fibers that transmit sensory signals to the brain (161)
Reason: Too much caffeine increases cortisol and encourages oxidative activity, which weakens antioxidant action
After four weeks on 0.5mg, the dose can be increased to 1.0mg (but doesnt have to be - many people can successfully lose all the weight they desire at 0.5mg)
(Teixeira et al., 2005)
Sin embargo, este efecto es modesto y transitorio, generalmente durando 30-60 minutos despus del consumo
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