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Unlike sermorelin, which mimics GHRH, ipamorelin stimulates GH release by activating the growth hormone secretagogue receptor (GHS-R), also known as the ghrelin receptor (5)

37 Among them, CHOP inhibits the expression of anti-apoptosis proteins B-cell lymphoma-2 (BCL-2) and B-cell lymphoma-extra-large (BCL-XL), inducing cell apoptosis, while TRIB3 inhibits Akt activity, promoting IR in insulin-target organs