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Why Patients Choose It: Lower cost (saves 6080%) Faster access during shortages Flexible dosing and additives like B12 Key Considerations: Not FDA-approved individually Quality varies by pharmacy

The trend warrants further investigation, as even modest reductions in hospitalization could have important clinical and economic implications if confirmed in larger datasets

Key Takeaway: Nausea is most common during the startup phase of treatment

Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]

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