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Strict health and safety protocols
PMID 11368417
Drug interactions have not been systematically evaluated
NNMT is a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, spending SAM and diverting nicotinamide away from the NAD+ salvage pathway
They are most often considered as a last resort for consistent supplementation if oral methods prove ineffective at staving off deficiency
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