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It is well known for being able to suppress somatostatin or growth hormone inhibiting hormone (GHIH)
Clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide) have demonstrated improvements in physical functioning and quality of life scores, which patients often interpret as increased energy
A trial of reperfusion therapy for ischemic stroke indicated that semaglutide, which has a strong GLP-1R-mediated neuroprotective effect, could reduce the infarct size in acute ischemic stroke in non-diabetic rats (89)
Chronic ingestion of alcohol is known to cause hepatic steatosis [69, 70]
2d,e and controls in Supplementary Fig
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