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Considering its potential impact on ghrelin receptors, Ipamorelin may enhance appetite, possibly leading to weight gain
Lancet 352:83753
Tirzepatide : Combines GLP-1 activity with another hormone, GIP (glucose-dependent insulinotropic polypeptide), enhancing its effects on appetite suppression and metabolic health
The physiologic concern is real, and retained gastric contents have been documented
Recent investigations reported that cerebral blood flow is usually increased by insulin, but that this action is blunted by insulin resistance, producing harmful effects such as mitochondrial dysfunction, oxidative stress, and decreased neuronal viability and eventually CD (van Sloten et al., 2020)
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