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"Triple-Hormone-Receptor Agonist Retatrutide for Obesity." NEJM 2023;389:514526
This guide walks through how it works, what the trials show, and how to think about it as a woman weighing your options
Conclusion: Master Your Maintenance Dose with Confidence Getting to your 2.4 mg dose is wonderful
doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date
Hormonal and cancer concerns: Animal studies suggest a possible link to thyroid tumors, leading to a boxed FDA warning, though human risk remains uncertain
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