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These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase
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Serotonin syndrome: Combining MDMA with MAO inhibitors, SSRIs, lithium, or other serotonergic agents precipitates serotonin syndrome, a potentially fatal triad of hyperthermia, neuromuscular abnormalities, and altered mental status requiring emergency intervention
The proband is now approximately over five years post the third and last major stroke
ChaC1 overexpression can augment apoptosis by activating caspase-3/9, degradation of poly (ADP ribose) polymerase, induction of autophagy, ROS generation, increased intracellular calcium and loss of mitochondrial membrane potential (69)
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