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Using boiling water
Clinical trials showed modest results, and AOD-9604 was not pursued through full FDA drug approval
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The substantial increase in plasma bile acid concentrations (primary, secondary, total and unconjugated bile acid concentrations) with metformin may be explained by the fact that metformin increased the abundance of probiotic bacteria, especially Lactobacillus , and thus their bile salt hydrolase (BSH) gene expression
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