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Conditions under active investigation include prediabetes, heart failure with preserved ejection fraction, obstructive sleep apnoea, knee osteoarthritis, polycystic ovarian syndrome, and inflammatory bowel disease
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Abundant studies support a non-redundant role for IGF-I signaling in mediatitng anabolic actions of PTH
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This pathway plays a major role in cell regulation including cell migration, cell proliferation, and apoptosis as well as being essential for embryonic development
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