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Int J Mol Sci (2021) 22(2):860

Other genes, although with ARE motifs, present CpG islands in their proximal promoters such as GCLC and GCLM, which are characterized by significant association of active histone codes such as H3K4Me1-3, H3K9Ac, H3K27Ac, and H3K79Me2, suggesting a regulatory role of CpG islands in chromatin modifications

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Pharmaceutical companies have a legal obligation to ensure their products are safe and to warn patients and doctors about all potential risks

38,39 Hypoxic and acidic conditions, driven by metabolic reprogramming, further dampen cytotoxic lymphocyte activity while promoting EMT and cancer stemness