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Hobart observed that many used a GLP-1 to reach a safer weight before surgery, discontinued the medication during the rapid weight loss that followed surgery, and later returned to it if weight regain occurred one or two years later
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However, researchers quickly realized that this localized elevation is not a sign of a healthy, robust immune system
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For example, under conditions of OGD, the local concentration of lactate increases, which triggers astrocyte responses by upregulating N-Myc downstream-regulated gene 2 (NDRG2) to alleviate the inflammatory state [136]
