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This broad tissue distribution explains why GLP-1 RAs exert effects on multiple organ systems simultaneously, a property that makes them particularly suited to address the complex pathophysiology of NASH, which involves dysregulation of glucose and lipid metabolism, insulin resistance, inflammation, and fibrosis
Headaches emerge as one of the most frequently reported side effects during the first weeks of semaglutide treatment, affecting approximately 1 in 4 patients according to clinical trial data
10.1210/en.2011-1070 187
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