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J Biol Chem 291:980988 Sayers SR, Reimann F, Gribble FM et al (2016) Proglucagon promoter cre-mediated AMPK deletion in mice increases circulating GLP-1 levels and oral glucose tolerance
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Like GHRS-R1a, the G protein-coupled GLP-1 receptor (GLP-1R) is also expressed in various regions of the CNS, including the hypothalamus, thalamus, brainstem, and cortical regions such as the insula, opercular cortex, frontal pole, and paracingulate gyrus (Drucker, 2022
Two compounds hitting the same mechanism would mostly add up to a stronger version of one mechanism
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