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NSAIDs can also affect kidney function, which is a critical consideration for people managing chronic conditions like diabetes
They can also be more painful and more prone to injection site reactions
There is also a possibility that the included studies reporting null or negative associations may be underrepresented in the published literature, leading to an overestimation of the observed association between GLP-1 RAs and CRC susceptibility
This fact, paired with the relatively short duration of follow-up, meant there were few renal outcomes and the benefits were largely extrapolated from reductions in proteinuria
However, since digestive side effects are more common at higher doses, the reduced level of Ozempic in your body means these side effects may also ease
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