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Peak plasma concentrations occur 8 to 72 hours post-injection, and steady-state concentrations are achieved after approximately 4 weeks of consistent weekly dosing

27 and Barrett et al

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Clinical pharmacology studies demonstrate that despite oral bioavailability of less than 1% compared to nearly complete absorption with subcutaneous injection, properly formulated oral tablets containing appropriately higher absolute doses achieve therapeutic blood concentrations sufficient for clinical appetite suppression, gastric emptying modulation, and metabolic effects comparable to injectable administration